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Antimicrobial Agents and Chemotherapy, December 2009, p. 5022-5025, Vol. 53, No. 12
0066-4804/09/$08.00+0     doi:10.1128/AAC.01026-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection{triangledown}

M. Mar Rodríguez,1 F. Javier Pastor,1 Enrique Calvo,1 Valentina Salas,1 Deanna A. Sutton,2 and Josep Guarro1*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain,1 Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas2

Received 22 July 2009/ Returned for modification 20 August 2009/ Accepted 15 September 2009

A broth microdilution method was used to evaluate the in vitro activities of seven antifungal agents against 15 clinical strains of Rhizopus microsporus. Amphotericin B (AMB) and posaconazole (POS) were the most active drugs. In a model of disseminated R. microsporus infection in immunosuppressed mice, we studied the efficacy of POS administered once or twice daily against four of the strains previously tested in vitro and compared it with that of liposomal AMB (LAMB). LAMB was the most effective treatment for the two strains with intermediate susceptibility to POS. For the two POS-susceptible strains, LAMB and POS at 20 mg/kg of body weight twice a day orally showed similar efficacies. The in vivo efficacy of POS administered twice a day orally correlated with the in vitro susceptibility data and the serum drug concentrations.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.cat

{triangledown} Published ahead of print on 28 September 2009.

Antimicrobial Agents and Chemotherapy, December 2009, p. 5022-5025, Vol. 53, No. 12
0066-4804/09/$08.00+0     doi:10.1128/AAC.01026-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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