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Antimicrobial Agents and Chemotherapy, February 2009, p. 782-784, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01122-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effect of Tigecycline against 14 Gram-Positive Organisms{triangledown}

G. A. Pankuch and P. C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 21 August 2008/ Returned for modification 13 November 2008/ Accepted 24 November 2008

The in vitro postantibiotic effects (PAEs), postantibiotic sub-MIC effects (PA-SMEs), and sub-MIC effects of tigecycline were determined for 14 gram-positive and gram-negative organisms. The pneumococcal, staphylococcal, and enterococcal PAEs were 1.9 to 5.1, 2.9 to 5.7, and 3.9 to 6.1 h, respectively, and those for Haemophilus influenzae, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii were 1.1 to 5.0, 1.9 to 2.1, 1.7 to 1.8, 1.0 to 1.7, and 0.7 to 3 h, respectively. The PA-SMEs (four times the MIC) ranged from 6.7 to >11 h for gram-positive organisms and from 2.3 to >11.3 h for gram-negative organisms.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 8 December 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 782-784, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01122-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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