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Antimicrobial Agents and Chemotherapy, February 2009, p. 798-799, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01126-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Preparation and Stability of Voriconazole Eye Drop Solution{triangledown}

Antoine Dupuis,1,2* Nicolas Tournier,1 Gwenaël Le Moal,1 and Nicolas Venisse1

Centre Hospitalier Universitaire de Poitiers, Poitiers, France,1 Faculté de Médecine et de Pharmacie, Université de Poitiers, Poitiers, France2

Received 22 August 2008/ Returned for modification 10 September 2008/ Accepted 29 October 2008

The combined systemic and topical administration of voriconazole has successfully been used to treat keratomycosis. Because no voriconazole eye drop product is commercially available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable over 30 days, providing an eye drop solution suitable for use for the topical treatment of fungal keratitis.

* Corresponding author. Mailing address: CHU Poitiers, Service Pharmacie, BP 577, 86021 Poitiers cedex, France. Phone: 33549443801. Fax: 33549443972. E-mail: Antoine.Dupuis{at}univ-poitiers.fr

{triangledown} Published ahead of print on 10 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 798-799, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01126-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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