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Antimicrobial Agents and Chemotherapy, February 2009, p. 800-804, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00603-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Ultrastructural Effects of Oritavancin on Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus{triangledown}

Adam Belley,1 Robert Harris,2 Terry Beveridge,2 Tom Parr Jr.,1 and Gregory Moeck1*

Targanta Therapeutics, Inc., 7170 Frederick Banting, St. Laurent, Quebec, Canada,1 MicroTEM Inc., P.O. Box 1107, 101 Chalmers St., Elora, Ontario, Canada N0B 1S02

Received 8 May 2008/ Returned for modification 4 August 2008/ Accepted 13 November 2008

The ultrastructural effects of the lipoglycopeptide oritavancin on methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE) were examined by transmission electron microscopy. Oritavancin but not vancomycin induced aberrant septum formation and loss of staining of nascent septal cross walls in MRSA. Septal distortions were also observed in VRE exposed to oritavancin.

* Corresponding author. Mailing address: Targanta Therapeutics Inc., 7170 Frederick Banting, St. Laurent, Quebec, Canada H4S 2A1. Phone: (514) 332-1008, ext. 232. Fax: (514) 332-6033. E-mail: gmoeck{at}targanta.com

{triangledown} Published ahead of print on 24 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 800-804, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00603-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Belley, A., Neesham-Grenon, E., McKay, G., Arhin, F. F., Harris, R., Beveridge, T., Parr, T. R. Jr., Moeck, G. (2009). Oritavancin Kills Stationary-Phase and Biofilm Staphylococcus aureus Cells In Vitro. Antimicrob. Agents Chemother. 53: 918-925 [Abstract] [Full Text]  


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