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Antimicrobial Agents and Chemotherapy, February 2009, p. 808-810, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00960-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Comparison of the Performances of Two In-House Rapid Methods for Antitubercular Drug Susceptibility Testing {triangledown}

Agustina I. de la Iglesia, Emma J. Stella, and Héctor R. Morbidoni*

Cátedra de Microbiología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina

Received 20 July 2008/ Returned for modification 3 September 2008/ Accepted 11 November 2008

Resistance to rifampin (rifampicin), isoniazid, and streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micromethod. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an option for drug resistance assessment of M. tuberculosis.

* Corresponding author. Mailing address: Cátedra de Microbiología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100 (2000) Rosario, Argentina. Phone: 54-341-4112029. Fax: 54-3414390465. E-mail: morbiatny{at}yahoo.com

{triangledown} Published ahead of print on 17 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 808-810, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00960-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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