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Antimicrobial Agents and Chemotherapy, February 2009, p. 814-817, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01132-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Activity of Levofloxacin Alone and in Combination with a DnaK Inhibitor against Gram-Negative Rods, Including Levofloxacin-Resistant Strains{triangledown}

Kim Credito,1 Gengrong Lin,1 Laura Koeth,2 Michael A. Sturgess,3 and Peter C. Appelbaum1*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033,1 Laboratory Specialists, Inc., Cleveland, Ohio 44106,2 Chaperone Technologies, Inc., East Stroudsburg, Pennsylvania 183013

Received 22 August 2008/ Returned for modification 22 October 2008/ Accepted 5 November 2008

Synergy time-kill testing of levofloxacin alone and in combination with CHP-105, a representative DnaK inhibitor, against 50 gram-negative rods demonstrated that 34 of the 50 strains tested showed significant synergy between levofloxacin and CHP-105 after 12 h and 24 h. Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of ≥4 µg/ml).

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 17 November 2008.

Antimicrobial Agents and Chemotherapy, February 2009, p. 814-817, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.01132-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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