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Antimicrobial Agents and Chemotherapy, February 2009, p. 818-820, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00987-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

First Report on a Hyperepidemic Clone of KPC-3-Producing Klebsiella pneumoniae in Israel Genetically Related to a Strain Causing Outbreaks in the United States {triangledown}

Shiri Navon-Venezia,1* Azita Leavitt,1 Mitchell J. Schwaber,1 J. Kamile Rasheed,2 Arjun Srinivasan,2 Jean B. Patel,2 Yehuda Carmeli,1 and the Israeli KPC Kpn Study Group {dagger}

Epidemiology Division, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv, Israel,1 Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 24 July 2008/ Returned for modification 25 September 2008/ Accepted 18 November 2008

A highly epidemic carbapenem-resistant clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak. This clone was genetically related to outbreak strains from the United States isolated in 2000 but differed in KPC-carrying plasmids. The threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted.

* Corresponding author. Mailing address: Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv 64239, Israel. Phone: 972-3-6925644. Fax: 972-3-6974332. E-mail: shiri_nv{at}tasmc.health.gov.il

{triangledown} Published ahead of print on 24 November 2008.

{dagger} Israeli KPC Kpn Study Group: B. Rubinovitch and I. Muskovitch, Rabin Medical Center, Petah-Tikva; O. Schwartz-Harari and M. Dan, Wolfsohn Medical Center, Holon; O. Zimhony and R. Bardenstein, Kaplan Medical Center, Rehovot; T. Lazarovitch, Assaf-Harofeh Medical Center, Zerifin; D. Schwartz, Sourasky Medical Center, Tel Aviv; Y. Keness and R. Raz, Ha'Emek Medical Center, Afula; and Z. Shimoni and S. Paikin, Laniado Hospital, Natanya, Israel.

Antimicrobial Agents and Chemotherapy, February 2009, p. 818-820, Vol. 53, No. 2
0066-4804/09/$08.00+0     doi:10.1128/AAC.00987-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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