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Antimicrobial Agents and Chemotherapy, March 2009, p. 1238-1241, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01433-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa{triangledown}

Tetsufumi Koga,* Chika Sugihara, Masayo Kakuta, Nobuhisa Masuda, Eiko Namba, and Takashi Fukuoka

Biological Research Laboratories IV, Daiichi Sankyo Co., Ltd., 16-13, 1-Chome Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan

Received 24 October 2008/ Returned for modification 25 November 2008/ Accepted 11 December 2008

Tomopenem (formerly CS-023), a novel 1β-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus, PBP 2 in Escherichia coli, and PBPs 2 and 3 in Pseudomonas aeruginosa, which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa, which correlated with the drug's PBP profiles. The potential of resistance of these bacteria to tomopenem was comparable to that to imipenem.

* Corresponding author. Mailing address: Biological Research Laboratories IV, Daiichi Sankyo Co., Ltd., 16-13, 1-Chome Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan. Phone: 81-3-5696-3915. Fax: 81-3-5696-4264. E-mail: koga.tetsufumi.zj{at}daiichisankyo.co.jp

{triangledown} Published ahead of print on 22 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1238-1241, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01433-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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