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Antimicrobial Agents and Chemotherapy, March 2009, p. 1252-1255, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01115-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Effects of Zidovudine and Stavudine on Mitochondrial DNA of Differentiating 3T3-F442a Cells Are Not Associated with Imbalanced Deoxynucleotide Pools{triangledown}

Matthew D. Lynx, Darcy D. LaClair, and Edward E. McKee*

Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, and Indiana University School of Medicine—South Bend, South Bend, Indiana 46617

Received 19 August 2008/ Returned for modification 22 October 2008/ Accepted 16 December 2008

To test whether zidovudine (3'-azido-3'-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

* Corresponding author. Mailing address: Indiana University School of Medicine—South Bend, 1234 Notre Dame Ave., South Bend, IN 46617. Phone: (574) 631-7193. Fax: (574) 631-7821. E-mail: mckee.6{at}nd.edu

{triangledown} Published ahead of print on 22 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1252-1255, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01115-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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