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Antimicrobial Agents and Chemotherapy, March 2009, p. 1268-1270, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01300-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Changes in aac(6')-Ib-cr Prevalence and Fluoroquinolone Resistance in Nosocomial Isolates of Escherichia coli Collected from 1991 through 2005{triangledown}

Gabriela Warburg,1 Maya Korem,1 Ari Robicsek,2 Dalia Engelstein,1 Allon E. Moses,1 Colin Block,1 and Jacob Strahilevitz1*

Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel,1 Department of Medicine, Medical Center, NorthShore University HealthSystem, 2650 Ridge Ave., Evanston, Illinois 602012

Received 29 September 2008/ Returned for modification 14 November 2008/ Accepted 11 December 2008

Clinical isolates of Escherichia coli collected from 1991 through 2005 at a tertiary-care center were studied for qnr and aac(6')-Ib-cr genes. Isolates bearing aac(6')-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence of aac(6')-Ib-cr was multiclonal and was associated with the presence of extended-spectrum β-lactamases.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein-Kerem, Jerusalem 91120, Israel. Phone: 972-50-894 6353. Fax: 972-2-641 9545. E-mail: jstrahilevitz{at}hadassah.org.il

{triangledown} Published ahead of print on 22 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1268-1270, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01300-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Strahilevitz, J., Jacoby, G. A., Hooper, D. C., Robicsek, A. (2009). Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat. Clin. Microbiol. Rev. 22: 664-689 [Abstract] [Full Text]  


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