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*Lyme Disease

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Antimicrobial Agents and Chemotherapy, March 2009, p. 1281-1284, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01247-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Borrelia spielmanii to Antimicrobial Agents Commonly Used for Treatment of Lyme Disease{triangledown}

Kristina Morgenstern,1* Georg Baljer,2 Douglas E. Norris,3 Peter Kraiczy,1 Christa Hanssen-Hübner,1 and Klaus-Peter Hunfeld1

Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul-Ehrlich-Str. 40, D-60596 Frankfurt/Main, Germany,1 Institute for Hygiene and Infectious Diseases of Animals, Justus Liebig University Giessen, Frankfurter Str. 85-89, D-35392 Giessen, Germany,2 Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolf Street, Baltimore, Maryland 212053

Received 19 September 2008/ Returned for modification 17 October 2008/ Accepted 8 December 2008

Ten isolates of the recently delineated genospecies Borrelia spielmanii were tested against antimicrobial agents used to treat Lyme disease and compared to eight isolates of the other three human-pathogenic borrelial genospecies. Despite some small but significant differences in four out of eight antibiotic agents, the susceptibility pattern of B. spielmanii mainly parallels that of the other known human-pathogenic members of the B. burgdorferi sensu lato complex.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Paul-Ehrlich Str. 40, D-60596 Frankfurt/Main, Germany. Phone: 49-69-6301-6441. Fax: 49-69-6301-5767. E-mail: Kristina.Morgenstern{at}vetmed.uni-giessen.de

{triangledown} Published ahead of print on 15 December 2008.

Antimicrobial Agents and Chemotherapy, March 2009, p. 1281-1284, Vol. 53, No. 3
0066-4804/09/$08.00+0     doi:10.1128/AAC.01247-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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