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Antimicrobial Agents and Chemotherapy, April 2009, p. 1619-1623, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01046-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Daptomycin versus Friulimicin B: In-Depth Profiling of Bacillus subtilis Cell Envelope Stress Responses{triangledown} ,{dagger}

Tina Wecke,1,4,# Daniela Zühlke,2,# Ulrike Mäder,3 Sina Jordan,1,4 Birgit Voigt,2 Stefan Pelzer,5,§ Harald Labischinski,5 Georg Homuth,3 Michael Hecker,2 and Thorsten Mascher1,4*

KIT Research Group 11-1, Karlsruhe Institute of Technology, Fritz-Haber-Weg 4, D-76131 Karlsruhe, Germany,1 Institute for Microbiology, Ernst-Moritz-Arndt-University, F.-L.-Jahn-Str. 15, D-17489 Greifswald, Germany,2 Interfaculty Institute for Genetics and Functional Genomics, Department for Functional Genomics, Ernst-Moritz-Arndt-University, Walther-Rathenau-Str. 49A, D-17489 Greifswald, Germany,3 Department of General Microbiology, Georg-August-University, Grisebachstr. 8, D-37077 Göttingen, Germany,4 MerLion Pharmaceuticals GmbH, Robert-Roessle-Str. 10, D-13125 Berlin, Germany5

Received 4 August 2008/ Returned for modification 7 November 2008/ Accepted 10 December 2008

The related lipo(depsi)peptide antibiotics daptomycin and friulimicin B show great potential in the treatment of multiply resistant gram-positive pathogens. Applying genome-wide in-depth expression profiling, we compared the respective stress responses of Bacillus subtilis. Both antibiotics target envelope integrity, based on the strong induction of extracytoplasmic function {sigma} factor-dependent gene expression. The cell envelope stress-sensing two-component system LiaRS is exclusively and strongly induced by daptomycin, indicative of different mechanisms of action in the two compounds.

* Corresponding author. Mailing address: Karlsruhe Institute of Technology (KIT), Institute of Applied Life Sciences, KIT Research Group 11-1 Microbial Stress Responses, Fritz-Haber-Weg 4, Building 30.43, Room 710, D-76131 Karlsruhe, Germany. Phone: 49 (0)721 608-3473. Fax: 49 (0)721 608-8932. E-mail: thorsten.mascher{at}kit.edu

{triangledown} Published ahead of print on 21 January 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

# These two authors contributed equally to this work.

§ Present address: BRAIN (Biotechnology Research And Information Network) AG, Darmstädter Str. 34, D-64673 Zwingenberg, Germany.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1619-1623, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01046-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hachmann, A.-B., Angert, E. R., Helmann, J. D. (2009). Genetic Analysis of Factors Affecting Susceptibility of Bacillus subtilis to Daptomycin. Antimicrob. Agents Chemother. 53: 1598-1609 [Abstract] [Full Text]  
  • Schneider, T., Gries, K., Josten, M., Wiedemann, I., Pelzer, S., Labischinski, H., Sahl, H.-G. (2009). The Lipopeptide Antibiotic Friulimicin B Inhibits Cell Wall Biosynthesis through Complex Formation with Bactoprenol Phosphate. Antimicrob. Agents Chemother. 53: 1610-1618 [Abstract] [Full Text]  


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