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Antimicrobial Agents and Chemotherapy, April 2009, p. 1645-1647, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01530-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Isavuconazole against Aspergillus Species and Zygomycetes According to the Methodology of the European Committee on Antimicrobial Susceptibility Testing{triangledown}

Susanne Perkhofer,* Veronika Lechner, and Cornelia Lass-Flörl

Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Innsbruck, Austria

Received 17 November 2008/ Returned for modification 12 December 2008/ Accepted 8 January 2009

We evaluated the MICs of isavuconazole (ISAV) against 96 isolates of Aspergillus species and 36 zygomycetes according to the methodology of the European Committee on Antimicrobial Susceptibility Testing. In addition, the in vitro activity was obtained for hyphal inocula. ISAV exhibited good antifungal activity against the tested isolates with the exception of Aspergillus niger and Mucorales. The in vitro activity of ISAV was comparable to that of voriconazole aside from Mucorales.

* Corresponding author. Mailing address: Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Innsbruck Medical University, Fritz Pregl Str. 3, 6020 Innsbruck, Austria. Phone: 43 512 9003 70729. Fax: 43 512 9003 73700. E-mail: Susanne.Perkhofer{at}i-med.ac.at

{triangledown} Published ahead of print on 21 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1645-1647, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01530-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Warn, P. A., Sharp, A., Parmar, A., Majithiya, J., Denning, D. W., Hope, W. W. (2009). Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect. Antimicrob. Agents Chemother. 53: 3453-3461 [Abstract] [Full Text]  


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