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Antimicrobial Agents and Chemotherapy, April 2009, p. 1652-1656, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00822-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Occurrence of Efflux Mechanism and Cephalosporinase Variant in a Population of Enterobacter aerogenes and Klebsiella pneumoniae Isolates Producing Extended-Spectrum β-Lactamases{triangledown}

Que-Tien Tran,1,3 Myrielle Dupont,1 Jean-Philippe Lavigne,1 Jacqueline Chevalier,1 Jean-Marie Pagès,1 Albert Sotto,2 and Anne Davin-Regli1*

Transporteurs Membranaires, Chimioresistance et Drug-Design, UMR-MD1, Facultés de Médecine et Pharmacie, Université de la Méditerranée, 13385 Marseille,1 INSERM, Espri 26, UFR Medecine, Universite Montpellier-1, 30029 Nîmes, France,2 Jacobs University Bremen, Campus Ring 1, School of Engineering and Science, D-28759 Bremen, Germany3

Received 23 June 2008/ Returned for modification 22 July 2008/ Accepted 15 January 2009

We investigated the occurrence of multidrug resistance in 44 Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Efflux was involved in resistance in E. aerogenes isolates more frequently than in K. pneumoniae isolates (100 versus 38% of isolates) and was associated with the expression of phenylalanine arginine β-naphthylamide-susceptible active efflux. AcrA-TolC overproduction in E. aerogenes isolates was noted. An analysis of four E. aerogenes isolates for which cefepime MICs were high revealed no modification in porin expression but a new specific mutation in the AmpC β-lactamase.

* Corresponding author. Mailing address: UMR-MD1, Faculté de Médecine, 27 Blvd. Jean-Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 45 29. Fax: (33) 4 91 32 46 06. E-mail: Anne.Regli{at}medecine.univ-mrs.fr

{triangledown} Published ahead of print on 21 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1652-1656, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.00822-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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