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Antimicrobial Agents and Chemotherapy, April 2009, p. 1670-1672, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01494-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Detection of Human Immunodeficiency Virus (HIV) Type 1 M184V and K103N Minority Variants in Patients with Primary HIV Infection{triangledown}

Thomas A. Toni,1,2,3 Eugene L. Asahchop,1 Daniela Moisi,1 Michel Ntemgwa,1 Maureen Oliveira,1 Bernard Masquelier,4 Bluma G. Brenner,1 and Mark A. Wainberg1,2*

McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2,1 Department of Medicine, McGill University, Montreal, Quebec H3A 2T5, Canada,2 Programme PACCI-CIRBA, Abidjan, Côte d'Ivoire,3 EA2968, Université de Bordeaux 2, Bordeaux, France4

Received 7 November 2008/ Returned for modification 19 December 2008/ Accepted 16 January 2009

We used an allele-specific real-time PCR assay to explore the presence of K103N and M184V minority species among primary human immunodeficiency virus (HIV) infections and their potential influence in HIV transmission. Thirty randomly chosen antiretroviral drug-naive patients lacking both the K103N and the M184V mutations as determined by conventional sequencing methods were studied, and K103N and M184V viral minority species were found in three (10%) and four (11%) patients, respectively.

* Corresponding author. Mailing address: McGill AIDS Centre, Jewish General Hospital, 3755 Cote Ste Catherine Rd., Montreal, Quebec, Canada H3T 1E2. Phone: (514) 340-8260. Fax: (514) 340-7537. E-mail: mark.wainberg{at}mcgill.ca

{triangledown} Published ahead of print on 26 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1670-1672, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01494-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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