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Antimicrobial Agents and Chemotherapy, April 2009, p. 1686-1689, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01467-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers{triangledown}

Ana Alastruey-Izquierdo, Maria Victoria Castelli, Isabel Cuesta, Araceli Monzon, Manuel Cuenca-Estrella, and Juan Luis Rodriguez-Tudela*

Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain

Received 3 November 2008/ Returned for modification 7 December 2008/ Accepted 19 January 2009

The antifungal susceptibility profiles of 77 clinical strains of Mucorales species, identified by internal transcribed spacer sequencing, were analyzed. MICs obtained at 24 and 48 h were compared. Amphotericin B was the most active agent against all isolates, except for Cunninghamella and Apophysomyces isolates. Posaconazole also showed good activity for all species but Cunninghamella bertholletiae. Voriconazole had no activity against any of the fungi tested. Terbinafine showed good activity, except for Rhizopus oryzae, Mucor circinelloides, and Rhizomucor variabilis isolates.

* Corresponding author. Mailing address: Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra. Majadahonda Pozuelo km 2 28220, Majadahonda, Spain. Phone: 34918223919. Fax: 34915097966. E-mail: jlrtudela{at}isciii.es

{triangledown} Published ahead of print on 26 January 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1686-1689, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01467-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rodriguez, M. M., Pastor, F. J., Calvo, E., Salas, V., Sutton, D. A., Guarro, J. (2009). Correlation of In Vitro Activity, Serum Levels, and In Vivo Efficacy of Posaconazole against Rhizopus microsporus in a Murine Disseminated Infection. Antimicrob. Agents Chemother. 53: 5022-5025 [Abstract] [Full Text]  


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