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Antimicrobial Agents and Chemotherapy, April 2009, p. 1698-1700, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01549-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection{triangledown}

Peter J. Petersen,1* C. Hal Jones,1 Aranapakam M. Venkatesan,2 and Patricia A. Bradford1

Infectious Disease Research,1 Chemical Sciences, Wyeth Research, Pearl River, New York2

Received 20 November 2008/ Returned for modification 22 December 2008/ Accepted 22 January 2009

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens.

* Corresponding author. Mailing address: Infectious Disease Research, Wyeth Research, Bldg. 200, Rm. 3301, 401 N. Middletown Rd., Pearl River, NY 10965. Phone: (845) 602-3070. Fax: (845) 602-5671. E-mail: petersp{at}wyeth.com

{triangledown} Published ahead of print on 2 February 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1698-1700, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01549-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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