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Antimicrobial Agents and Chemotherapy, April 2009, p. 1705-1708, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01606-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Interactions between Triazoles and Amphotericin B in Treatment of Disseminated Murine Infection by Fusarium oxysporum{triangledown}

Mery Ruíz-Cendoya, Marçal Mariné, M. M. Rodríguez, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain

Received 4 December 2008/ Returned for modification 7 January 2009/ Accepted 25 January 2009

We have evaluated and compared the efficacies of high doses of amphotericin B (AMB; 3 mg/kg of body weight/day), voriconazole (60 mg/kg), and posaconazole (PSC; 100 mg/kg) alone and combined in a murine model of disseminated infection by Fusarium oxysporum. The combination of AMB with PSC showed the best results, prolonging the survival of mice and reducing their organ fungal loads. This combination might constitute a therapeutic option for those infections where monotherapies fail.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.cat

{triangledown} Published ahead of print on 2 February 2009.

Antimicrobial Agents and Chemotherapy, April 2009, p. 1705-1708, Vol. 53, No. 4
0066-4804/09/$08.00+0     doi:10.1128/AAC.01606-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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