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Antimicrobial Agents and Chemotherapy, May 2009, p. 1921-1925, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01065-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of Macrolide Efflux Pump mef Subclasses Detected in Clinical Isolates of Streptococcus pyogenes Isolated between 1999 and 2005{triangledown}

J. Blackman Northwood,1* M. Del Grosso,2 L. R. Cossins,1 M. D. Coley,1 R. Creti,2 A. Pantosti,2 and D. J. Farrell1

Quotient Bioresearch Ltd., Fordham, United Kingdom,1 Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy2

Received 7 August 2008/ Returned for modification 7 November 2008/ Accepted 20 February 2009

The macrolide efflux mechanism of resistance, mef, was characterized in community-acquired respiratory tract infections with Streptococcus pyogenes. Fifty-four (4.6%) M phenotype isolates were screen tested as negative for mef(A). Of these 54 isolates, 5 (0.4%), 27 (2.3%), and 1 (0.1%) were considered to be mef(I) positive, a novel mosaic variant of mef, or a novel subclass of mef, respectively. This study shows (i) the definitive presence of mef(E) in S. pyogenes and its global distribution, (ii) the presence of a mosaic variant of mef composed of mef(A) and mef(E), (iii) the previously undescribed presence of mef(I) in S. pyogenes, and (iv) the presence of a novel subclass of mef in S. pyogenes.

* Corresponding author. Mailing address: Quotient Bioresearch Limited, Newmarket Road, Fordham CB7 5WW, United Kingdom. Phone: 44 (0)1638 720 500. Fax: 44 (0)1638 724 200. E-mail: John.BlackmanNorthwood{at}quotientbioresearch.com

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 1921-1925, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01065-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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