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Antimicrobial Agents and Chemotherapy, May 2009, p. 2129-2132, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01598-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796{triangledown}

Matthew F. McCown, Sonal Rajyaguru, Simran Kular, Nick Cammack, and Isabel Nájera*

Roche Palo Alto LLC, 3431 Hillview Ave., Palo Alto, California 94304

Received 2 December 2008/ Returned for modification 16 January 2009/ Accepted 25 February 2009

In vitro, telaprevir selects subtype-specific resistance pathways for hepatitis C virus GT-1a and GT-1b, as described to have occurred in patients. In GT-1a, the HCV-796 resistance mutation C316Y has low replication capacity (7%) that can be compensated for by the emergence of the mutation L392F or M414T, resulting in an increase in replication levels of ≥10-fold.

* Corresponding author. Mailing address: Department of HCV Drug Discovery and Resistance Monitoring, Virology DBA, Roche Palo Alto LLC, 3431 Hillview Ave., Palo Alto, CA 94304. Phone: (650) 855-5134. Fax: (650) 354-7554. E-mail: isabel.najera{at}roche.com

{triangledown} Published ahead of print on 9 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2129-2132, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01598-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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