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Antimicrobial Agents and Chemotherapy, May 2009, p. 2133-2135, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01271-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Does the Activity of the Combination of Imipenem and Colistin In Vitro Exceed the Problem of Resistance in Metallo-β-Lactamase-Producing Klebsiella pneumoniae Isolates?{triangledown}

Maria Souli,* Panagiota Danai Rekatsina, Zoi Chryssouli, Irene Galani, Helen Giamarellou, and Kyriaki Kanellakopoulou

4th Department of Internal Medicine, Athens University School of Medicine, University General Hospital Attikon, Chaidari, Greece

Received 23 September 2008/ Returned for modification 30 December 2008/ Accepted 19 February 2009

Using time-kill methodology, we investigated the interactions of an imipenem-colistin combination against 42 genetically distinct Klebsiella pneumoniae clinical isolates carrying a blaVIM-1-type gene. Irrespective of the imipenem MIC, the combination was synergistic (50%) or indifferent (50%) against colistin-susceptible strains, while it was antagonistic (55.6%) and rarely synergistic (11%) against non-colistin-susceptible strains (with synergy being observed only against strains with colistin MICs of 3 to 4 µg/ml). The combination showed improved bactericidal activity against isolates susceptible either to both agents or to colistin.

* Corresponding author. Mailing address: University General Hospital Attikon, 1 Rimini Str 124 62, Chaidari 124 62, Greece. Phone: 210 5831643. Fax: 210 5326446. E-mail: msouli{at}med.uoa.gr

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2133-2135, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01271-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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