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Antimicrobial Agents and Chemotherapy, May 2009, p. 2136-2138, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01506-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Terbinafine Combined with Caspofungin and Azoles against Pythium insidiosum{triangledown}

Ayrton S. Cavalheiro,1,2 Grazieli Maboni,2 Maria I. de Azevedo,2 Juliana S. Argenta,2 Daniela I. B. Pereira,2 Tatiana B. Spader,2,3 Sydney H. Alves,1,2,3 and Janio M. Santurio1,2*

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil,1 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil,3 Laboratório de Pesquisas Micológicas (LAPEMI), Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil2

Received 11 November 2008/ Returned for modification 18 December 2008/ Accepted 4 March 2009

In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

* Corresponding author. Mailing address: Campus UFSM, Prédio 20, sala 4139, 97105-900 Santa Maria, RS, Brazil. Phone and fax: 55 55 32208906. E-mail: santurio{at}smail.ufsm.br

{triangledown} Published ahead of print on 16 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2136-2138, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01506-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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