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Antimicrobial Agents and Chemotherapy, May 2009, p. 2145-2148, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01163-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Bactericidal Activity of the Combination of Levofloxacin with Rifampin in Experimental Prosthetic Knee Infection in Rabbits Due to Methicillin-Susceptible Staphylococcus aureus{triangledown}

Claudette Muller-Serieys,1 Azzam Saleh Mghir,2,{dagger} Laurent Massias,3 and Bruno Fantin2*

Laboratoire de Microbiologie, AP-HP, Hôpital Bichat,1 EA3964, Université Paris Diderot,2 Laboratoire de Toxicologie-Pharmacocinétique, Service de Pharmacie, AP-HP, Hôpital Bichat, Paris, France3

Received 29 August 2008/ Returned for modification 27 December 2008/ Accepted 26 February 2009

The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.

* Corresponding author. Mailing address: Hôpital Beaujon, Service de Médecine Interne, 100 Boulevard du Général Leclerc, 92110 Clichy, France. Phone: 33 1 40 87 58 90. Fax: 33 1 40 87 10 81. E-mail: bruno.fantin{at}bjn.aphp.fr

{triangledown} Published ahead of print on 9 March 2009.

{dagger} Present address: EA3647, PIFO Université Versailles Saint Quentin en Yvelines, France.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2145-2148, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01163-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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