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Antimicrobial Agents and Chemotherapy, May 2009, p. 2158-2159, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01563-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China{triangledown}

Deli Xin,1* Zuhuang Mi,2 Xu Han,3 Ling Qin,2 Jing Li,1 Tianli Wei,1 Xiaogeng Chen,1 Shaojie Ma,1 Ancun Hou,1 Gui Li,1 and Dawei Shi1

Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China,1 Wuxi Research Institute of Genetics & Cloning Technology, Wuxi, Jiangsu 214026, China,2 Department of Pediatrics, Central Hospital of China National Petroleum Corporation, Langfang, Hebei 065000, China3

Received 24 November 2008/ Returned for modification 22 December 2008/ Accepted 22 February 2009

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.

* Corresponding author. Mailing address: Pediatric Department of Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, XuanWu District, Beijing 100050, China. Phone: 86-010-63138404. Fax: 86-010-63023261. E-mail: xindl48{at}sina.com.cn

{triangledown} Published ahead of print on 9 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2158-2159, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01563-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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