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Antimicrobial Agents and Chemotherapy, May 2009, p. 2163-2170, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01557-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antianaerobic Activity of Sulopenem Compared to Six Other Agents {triangledown}

Lois M. Ednie and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 21 November 2008/ Returned for modification 19 December 2008/ Accepted 9 January 2009

Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 431 anaerobes. Overall, MIC50/90 values were as follows: sulopenem, 0.25/1.0 µg/ml; amoxicillin/clavulanate, 0.5/2.0 µg/ml; ampicillin/sulbactam, 0.5/4.0 µg/ml; piperacillin/tazobactam, 0.25/8.0 µg/ml; imipenem, 0.06/1.0 µg/ml; clindamycin, 0.25/16.0 µg/ml; and metronidazole, 1.0/4.0 µg/ml.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 17 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2163-2170, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01557-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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