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Antimicrobial Agents and Chemotherapy, May 2009, p. 2171-2175, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00129-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates{triangledown}

Helio S. Sader,1,2* Thomas R. Fritsche,1,{dagger} and Ronald N. Jones1,3

JMI Laboratories, North Liberty, Iowa,1 Universidade Federal de São Paulo, São Paulo, Brazil,2 Tufts University School of Medicine, Boston, Massachusetts3

Received 28 January 2009/ Returned for modification 18 February 2009/ Accepted 5 March 2009

The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. In addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.

* Corresponding author. Mailing address: JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. Phone: (319) 665-3370. Fax: (319) 665-3371. E-mail: helio-sader{at}jmilabs.com

{triangledown} Published ahead of print on 16 March 2009.

{dagger} Present address: Marshfield Clinic, 1000 N. Oak Ave., Marshfield, WI 54449.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2171-2175, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.00129-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Krievins, D., Brandt, R., Hawser, S., Hadvary, P., Islam, K. (2009). Multicenter, Randomized Study of the Efficacy and Safety of Intravenous Iclaprim in Complicated Skin and Skin Structure Infections. Antimicrob. Agents Chemother. 53: 2834-2840 [Abstract] [Full Text]  


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