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Antimicrobial Agents and Chemotherapy, May 2009, p. 2176-2180, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01566-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Binding of Faropenem and Other β-Lactam Agents to Penicillin-Binding Proteins of Pneumococci with Various β-Lactam Susceptibilities{triangledown}

Klaudia Kosowska-Shick, Pamela McGhee, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania

Received 24 November 2008/ Returned for modification 6 February 2009/ Accepted 11 February 2009

Faropenem demonstrated low MICs (≤1 µg/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to Streptococcus pneumoniae penicillin-binding proteins (PBPs), except for PBP2X. The lower faropenem affinity for PBP2X did not affect MICs for any strains tested, and only imipenem had lower MICs, with much lower binding affinities for all PBPs tested, than faropenem.

* Corresponding author. Mailing address: 500 University Dr., Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 23 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2176-2180, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01566-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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