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Antimicrobial Agents and Chemotherapy, May 2009, p. 2181-2184, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01413-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Fenticonazole Activity Measured by the Methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida Vulvovaginitis Isolates from Two European Regions and Annotations on the Prevalent Genotypes{triangledown}

Stavroula Antonopoulou,1,2,4 Michel Aoun,2 Evangelos C. Alexopoulos,3 Stavroula Baka,1 Emanuel Logothetis,1 Theodoros Kalambokas,4,5 Andreas Zannos,4,6 Konstantine Papadias,5 Odysseas Grigoriou,5 Evangelia Kouskouni,1,{dagger} and Aristea Velegraki4,{dagger}*

Department of Bacteriology and Biochemistry, University of Athens, Aretaieion Hospital Athens, Athens, Greece,1 Institute Jules Bordet, ULB, Brussels, Belgium,2 Department of Public Health, Medical School, University of Patras, Patras, Greece,3 Mycology Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece,4 Second Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece,5 Microbiology Laboratory, 401 Military Hospital, Athens, Greece6

Received 21 October 2008/ Returned for modification 12 December 2008/ Accepted 6 February 2009

The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient (P < 0.0001). Also, the levels of agreement for the results for itraconazole, fluconazole, and ketoconazole were 84%, 90%, and 98% (P < 0.0001), respectively. Multilocus typing by PCR fingerprinting and subsequent cluster analysis delineated geographically associated alignments for Candida albicans and fluconazole resistance-related clusters for Candida glabrata.

* Corresponding author. Mailing address: Mycology Laboratory, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 115 27 Athens, Greece. Phone: 302107462146. Fax: 302107462147. E-mail: aveleg{at}med.uoa.gr

{triangledown} Published ahead of print on 17 February 2009.

{dagger} These authors contributed equally.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2181-2184, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01413-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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