This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seed, K. D.
Right arrow Articles by Dennis, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seed, K. D.
Right arrow Articles by Dennis, J. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 2009, p. 2205-2208, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01166-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex {triangledown}

Kimberley D. Seed and Jonathan J. Dennis*

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9

Received 29 August 2008/ Returned for modification 23 September 2008/ Accepted 3 February 2009

The Burkholderia cepacia complex (BCC) is a group of bacterial pathogens that are highly antibiotic resistant and associated with debilitating respiratory infections. Although bacteriophages of the BCC have been isolated and characterized, no studies have yet examined phage therapy against the BCC in vivo. In a caterpillar infection model, we show that BCC phage therapy is an alternative treatment possibility and is highly effective under specific conditions.

* Corresponding author. Mailing address: Department of Biological Sciences, University of Alberta, M354 Biological Sciences Building, Edmonton, Alberta, Canada T6G 2E9. Phone: (780) 492-2529. Fax: (780) 492-9234. E-mail: jon.dennis{at}ualberta.ca

{triangledown} Published ahead of print on 17 February 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2205-2208, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01166-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»