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Antimicrobial Agents and Chemotherapy, May 2009, p. 2212-2214, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01469-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Statins as Potential Antimalarial Drugs: Low Relative Potency and Lack of Synergy with Conventional Antimalarial Drugs{triangledown}

Rina P. M. Wong and Timothy M. E. Davis*

School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia

Received 3 November 2008/ Returned for modification 13 January 2009/ Accepted 12 February 2009

The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of ≥17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.

* Corresponding author. Mailing address: University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia. Phone: 618 9431 3229. Fax: 618 9431 2977. E-mail: tdavis{at}cyllene.uwa.edu.au

{triangledown} Published ahead of print on 2 March 2009.

Antimicrobial Agents and Chemotherapy, May 2009, p. 2212-2214, Vol. 53, No. 5
0066-4804/09/$08.00+0     doi:10.1128/AAC.01469-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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