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Antimicrobial Agents and Chemotherapy, June 2009, p. 2629-2631, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01026-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antifungal Combinations against Simulated Candida albicans Endocardial Vegetations{triangledown}

Manjunath P. Pai*

College of Pharmacy, University of New Mexico, Albuquerque, New Mexico

Received 31 July 2008/ Returned for modification 13 November 2008/ Accepted 12 March 2009

The in vitro effects of flucytosine (5FC), liposomal amphotericin B (L-AmB), and micafungin (Mica) combinations against two Candida albicans strains that simulated 24-hour-old endocardial vegetations were studied. Mica was superior to 5FC or L-AmB, and the 5FC-L-AmB-Mica combination was superior to all other treatments for one strain but no different from the dual combination of L-AmB-Mica for the other strain.

* Mailing address: Institute for Clinical Pharmacodynamics, Ordway Research Institute, 43 British American Blvd., Latham, NY 12110. Phone: (518) 429-2707. Fax: (518) 429-2701. E-mail: apai-icpd{at}OrdwayResearch.org

{triangledown} Published ahead of print on 23 March 2009.

Antimicrobial Agents and Chemotherapy, June 2009, p. 2629-2631, Vol. 53, No. 6
0066-4804/09/$08.00+0     doi:10.1128/AAC.01026-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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