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Antimicrobial Agents and Chemotherapy, July 2009, p. 3030-3033, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00952-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone{triangledown}

U. Egermann,1 Z. Stanga,1 A. Ramin,4 F. Acosta,1 A. Stucki,1 P. Gerber,2 M. Cottagnoud,3 and P. Cottagnoud4*

Department of Internal Medicine, Inselspital, Bern, Switzerland,1 Clinic for Pneumology, Inselspital, Bern, Switzerland,2 Clinic for Internal Medicine, Spitalnetz Bern Ziegler, Bern, Switzerland,3 Clinic for Internal Medicine, Klinik Sonnenhof, Bern, Switzerland4

Received 18 July 2008/ Returned for modification 13 November 2008/ Accepted 29 March 2009

We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal meningitis. The previous addition of dexamethasone affected the antibacterial activity of daptomycin only marginally, either as monotherapy or combined with ceftriaxone, although the penetration of daptomycin into inflamed meninges was significantly reduced from 6 to 2%. Daptomycin with ceftriaxone might be a potential candidate for the empirical therapy of bacterial meningitis, although the activity of this regimen against Listeria monocytogenes remains to be demonstrated.

* Corresponding author. Mailing address: Clinic for Internal Medicine, Klinik Sonnenhof, Bern, Switzerland. Phone: 41-31-358-12-83. Fax: 41-31-358-19-35. E-mail: philippecottagnoud{at}sonnenhof.ch

{triangledown} Published ahead of print on 13 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3030-3033, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00952-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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