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Antimicrobial Agents and Chemotherapy, July 2009, p. 3097-3099, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01552-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Sitafloxacin Activity against Helicobacter pylori Isolates, Including Those with gyrA Mutations{triangledown}

Kazunari Murakami,1 Tadayoshi Okimoto,1 Masaaki Kodama,1 Jin Tanahashi,1 Toshio Fujioka,1 Fumiaki Ikeda,2 Hiroe Muraoka,2 Motoko Takigawa,2 Takeshi Saika,2 Miyuki Hasegawa,2 and Intetsu Kobayashi3*

Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaiga-oka, Hasama-machi, Oita 879-5593, Japan,1 Chemotherapy Division, Mitsubishi Chemical Medience Corporation, 3-30-1 Shimura, Itabashi-ku, Tokyo 174-8555, Japan,2 Toho University School of Medicine, 4-16-20 Omori-nishi, Ota-ku, Tokyo 143-0015, Japan3

Received 20 November 2008/ Returned for modification 17 December 2008/ Accepted 6 April 2009

Sitafloxacin showed MICs of less than or equal to 0.5 µg/ml against 105 isolates of Helicobacter pylori, including 44 isolates with mutations in the gyrA gene. The highest MICs for garenoxacin and levofloxacin were 8 and 64 times, respectively, higher than the highest MICs observed for sitafloxacin.

* Corresponding author. Mailing address: Toho University School of Medicine, 4-16-20 Omori-nishi, Ota-ku, Tokyo 143-0015, Japan. Phone and fax: 81-3-3762-9247. E-mail: kobatora{at}ja2.so-net.ne.jp

{triangledown} Published ahead of print on 20 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3097-3099, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01552-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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