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Antimicrobial Agents and Chemotherapy, July 2009, p. 3100-3102, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00001-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Reduction of Amphotericin B-Induced Renal Tubular Apoptosis by N-Acetylcysteine{triangledown}

Z. Odabasi,1* A. Karaalp,1 H. Cermik,2 J. Mohr,3 E. T. Tigen,1 M. Koc,1 and V. Korten1

Marmara University School of Medicine, Istanbul, Turkey,1 Etimesgut Military Hospital, Ankara, Turkey,2 University of Texas—Houston Medical School, Houston, Texas3

Received 1 January 2009/ Returned for modification 6 February 2009/ Accepted 23 April 2009

The reduction of amphotericin B (AmB)-induced renal tubular apoptosis and nephrotoxicity by N-acetylcysteine (NAC) in a murine model was evaluated. Four groups of rats were treated with AmB for 5 days, and each group concomitantly received two doses of 30, 60, or 120 mg of NAC/kg of body weight/day or sterile water for 5 days. Groups that received concomitant NAC at any dose had significantly decreased levels of apoptosis compared to that in animals receiving AmB only (48.8% versus 27.4, 23.6, or 23.5%, respectively; P < 0.001).

* Corresponding author. Mailing address: Marmara University Hospital, Department of Infectious Diseases, Tophanelioglu caddesi, Altunizade, Istanbul, Turkey. Phone and fax: 90 216 3274142. E-mail: zekaver{at}marmara.edu.tr

{triangledown} Published ahead of print on 4 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3100-3102, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00001-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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