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Antimicrobial Agents and Chemotherapy, July 2009, p. 3108-3111, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00160-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Echinocandins against Candida krusei Determined by Three Methods: MIC and Minimal Fungicidal Concentration Measurements and Time-Kill Studies{triangledown}

Emilia Cantón,1* Javier Pemán,2 Amparo Valentín,1 Ana Espinel-Ingroff,3 and Miguel Gobernado2

Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario La Fe, Valencia 46009, Spain,1 Servicio de Microbiología, Hospital Universitario La Fe, Valencia 46009, Spain,2 Division of Infectious Disease, VCU Medical Center, Richmond, Virginia3

Received 4 February 2009/ Returned for modification 21 March 2009/ Accepted 14 April 2009

We evaluated the in vitro activities of anidulafungin, micafungin, and caspofungin against Candida krusei by determining MIC and minimum fungicidal concentration (MFC) measurements and by the time-kill method. The geometric mean (GM)-MIC/GM-MFC values were 0.1/0.34, 0.25/0.44, and 1/2.29, respectively. The mean times to reach 99.9% growth reduction were 19.1 ± 18.2 h (mean ± standard deviation) for 2 mg/liter anidulafungin, 37.4 ± 8.8 h for 2 mg/liter caspofungin, and 30.7 ± 12.2 h for 1 mg/liter micafungin. Anidulafungin exhibited the highest time-kill rate, followed by micafungin. The three echinocandins showed fungicidal activity at concentrations reached in serum.

* Corresponding author. Mailing address: Unidad de Microbiología Experimental Centro de Investigación, Hospital Universitario La Fe, Avenida Campanar 21, 46009 Valencia, Spain. Phone: 34 96 1973111. Fax: 34 96 3868718. E-mail: canton_emi{at}gva.es

{triangledown} Published ahead of print on 20 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3108-3111, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00160-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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