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Antimicrobial Agents and Chemotherapy, July 2009, p. 3118-3121, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00183-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Resistance Selection Studies Comparing the Activity of Razupenem (PTZ601) to Vancomycin and Linezolid against Eight Methicillin-Resistant and Two Methicillin-Susceptible Staphylococcus aureus Strains{triangledown}

Catherine Clark, Klaudia Kosowska-Shick, Pamela McGhee, Bonifacio Dewasse, Linda Beachel, and Peter C. Appelbaum*

Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 10 February 2009/ Returned for modification 5 April 2009/ Accepted 5 May 2009

Multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against 10 methicillin (meticillin)-resistant and -susceptible Staphylococcus aureus strains. After 20 daily subcultures, razupenem yielded only clones with MICs of >4 µg/ml in one strain (8 µg/ml) whose parent's MIC was already 4 µg/ml. After 18 to 49 passages in 6/10 strains, razupenem MICs rose from 0.016 to 2 µg/ml (parents) to 0.125 to 8 µg/ml (with clones stable after 10 drug-free subcultures). Single-step mutant selection frequencies were similarly low for razupenem and comparators.

* Corresponding author. Mailing address: Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu

{triangledown} Published ahead of print on 11 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3118-3121, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00183-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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