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Antimicrobial Agents and Chemotherapy, July 2009, p. 3126-3130, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01353-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of Cefoxitin-Resistant Escherichia coli Isolates from Recreational Beaches and Private Drinking Water in Canada between 2004 and 2006 {triangledown} ,{dagger}

L. F. Mataseje,1,3 N. Neumann,2,4 B. Crago,5 P. Baudry,1 G. G. Zhanel,1 M. Louie,2,5 M. R. Mulvey,1,3* and the ARO Water Study Group,5

University of Manitoba, Winnipeg, Manitoba, Canada,1 Alberta Provincial Public Health Laboratory, Calgary, Alberta, Canada,2 National Microbiology Laboratory, Winnipeg, Manitoba, Canada,3 University of Alberta, Edmonton, Alberta, Canada,4 University of Calgary, Calgary, Alberta, Canada5

Received 9 October 2008/ Returned for modification 3 November 2008/ Accepted 29 March 2009

A total of 142 cefoxitin-resistant Escherichia coli isolates from water sources were collected across Canada. Multidrug resistance was observed in 65/142 (45.8%) isolates. The blaCMY-2 gene was identified in 110/142 (77.5%) isolates. Sequencing of the chromosomal ampC promoter region showed mutations from the wild type, previously shown to hyperproduce AmpC. CMY-2-producing plasmids predominantly belonged to replicon groups I1-I{gamma}, A/C, and K/B. The majority of the E. coli isolates belonged to the nonvirulent phylogenetic groups A and B1.

* Corresponding author. Mailing address: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg R3E 3R2, Manitoba, Canada. Phone: (204) 789-5000. Fax: (204) 789-5020. E-mail: Michael_Mulvey{at}phac-aspc.gc.ca

{triangledown} Published ahead of print on 27 April 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3126-3130, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01353-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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