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Antimicrobial Agents and Chemotherapy, July 2009, p. 3143-3146, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01473-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

First Detection of Plasmid-Encoded blaOXY β-Lactamase{triangledown}

J. J. González-López,* A. Coelho, M. N. Larrosa, S. Lavilla, R. Bartolomé, and G. Prats

Department of Microbiology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

Received 4 November 2008/ Returned for modification 1 February 2009/ Accepted 13 April 2009

Three Klebsiella oxytoca isolates and one Klebsiella pneumoniae isolate from three children admitted to the Hematology Unit of Hospital Vall d'Hebron (Barcelona, Spain) exhibited a susceptibility pattern suggesting OXY β-lactamase hyperproduction. All the isolates contained a 95-kb plasmid that harbored blaOXY-1, which was transferred by electrotransformation but could not be self-transferred by conjugation. A qnrS1 gene was also harbored in the blaOXY-1-carrying plasmid. This is the first report of a plasmid-encoded OXY β-lactamase.

* Corresponding author. Mailing address: Department of Microbiology, Hospital Vall d'Hebron, Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain. Phone: 34-93-2746867. Fax: 34-93-2746801. E-mail: jjgonzalez{at}ir.vhebron.net

{triangledown} Published ahead of print on 20 April 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3143-3146, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01473-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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