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Antimicrobial Agents and Chemotherapy, July 2009, p. 3153-3155, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01700-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Prospective Open-Label Study of the Administration of Two-Percent Voriconazole Eye Drops{triangledown}

Daoud Al-Badriyeh,1 Lok Leung,2 Trent Roydhouse,3 Robert Fullinfaw,4 Mark Daniell,3 Geoffrey E. Davies,2 Kay Stewart,1 and David C. M. Kong1*

Department of Pharmacy Practice, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia,1 Pharmacy Department, Royal Victorian Eye and Ear Hospital, Melbourne, Australia,2 Ophthalmology Department, Royal Victorian Eye and Ear Hospital, Melbourne, Australia,3 Pathology Department, Royal Melbourne Hospital, Melbourne, Australia4

Received 23 December 2008/ Returned for modification 24 March 2009/ Accepted 5 May 2009

Thirteen human subjects scheduled for elective anterior segment eye surgery received hourly 2% voriconazole eye drops 4 hours presurgery. No side effects were reported. Significantly, the voriconazole concentration in the aqueous humor of the eye was similar to that reported for the 1% voriconazole solution, suggestive of concentration-independent absorption.

* Corresponding author. Mailing address: Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. Phone: 61 (0)3 9903 9035. Fax: 61 (0)3 9903 9629. E-mail: david.kong{at}pharm.monash.edu.au

{triangledown} Published ahead of print on 11 May 2009.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3153-3155, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.01700-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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