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Antimicrobial Agents and Chemotherapy, July 2009, p. 3156-3158, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00110-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antiretroviral Drug Resistance Surveillance among Treatment-Naive Human Immunodeficiency Virus Type 1-Infected Individuals in Angola: Evidence for Low Level of Transmitted Drug Resistance{triangledown} ,{dagger}

Inês Bártolo,1 Cheila Rocha,1 José Bartolomeu,2 António Gama,3 Marlene Fonseca,4 Ana Mendes,4 Filipa Cristina,5 Sven Thamm,6 Marta Epalanga,2 Patrícia Cavaco Silva,1,7 and Nuno Taveira1,7*

Unidade dos Retrovírus e Infecções Associadas, Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal,1 Serviço Nacional de Sangue, Luanda, Angola,2 Malongo, Medical Department, Cabinda, Angola,3 Hospital Militar Principal, Luanda, Angola,4 Abbott Molecular, Amadora, Portugal,5 Abbott GmbH & Co. KG, Wiesbaden, Germany,6 Instituto Superior de Ciências da Saúde Egas Moniz, Monte de Caparica, Portugal7

Received 26 January 2009/ Returned for modification 4 March 2009/ Accepted 30 April 2009

The prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Two (1.6%) unrelated patients harbored nucleoside reverse transcriptase inhibitor- and nonnucleoside reverse transcriptase inhibitor-resistant viruses (mutations: M41L, D67N, M184V, L210W, T215Y or T215F, and K103N). Continued surveillance of drug resistance is required for maximization of ART efficacy in Angola.

* Corresponding author. Mailing address: Unidade dos Retrovírus e Infecções Associadas, Centro de Patogénese Molecular, Faculdade de Farmácia de Lisboa, Avenida das Forças Armadas, 1649-019 Lisboa, Portugal. Phone: 351217934212. Fax: 351217986055. E-mail: ntaveira{at}ff.ul.pt

{triangledown} Published ahead of print on 11 May 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, July 2009, p. 3156-3158, Vol. 53, No. 7
0066-4804/09/$08.00+0     doi:10.1128/AAC.00110-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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