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Antimicrobial Agents and Chemotherapy, August 2009, p. 3266-3268, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01670-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Intravenous Piperacillin Administration in Patients Undergoing On-Line Hemodiafiltration{triangledown}

Kook-Hwan Oh,1,2 Chiweon Kim,1 Hankyu Lee,1 Hajeong Lee,1 Ji Yong Jung,1 Nam Joong Kim,1 Kyung-Sang Yu,3 Kwang-Hee Shin,3 In-Jin Jang,3* and Curie Ahn1,2*

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea,1 Transplantation Research Institute, Seoul National University, Seoul, Korea,2 Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital, Seoul, South Korea3

Received 19 December 2008/ Returned for modification 27 February 2009/ Accepted 8 May 2009

The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin sodium intravenously over 1 min and placed on on-line HDF for 4 h starting at 60 min after the piperacillin infusion. Noncompartmental models were employed for estimation of the pharmacokinetic parameters, and intradialytic piperacillin clearance was calculated by the recovery method. The mean volume of distribution and the elimination half-life were 0.27 ± 0.13 liter/kg (mean ± standard deviation) and 1.1 ± 0.6 h, respectively. The total body clearance of piperacillin was 0.19 ± 0.08 liter/h/kg. Piperacillin clearance through on-line HDF was 0.11 ± 0.06 liter/h/kg. The mean serum piperacillin concentration was 4.0 ± 1.9 µg/ml at the end of the 4-h on-line HDF session. The concentration of infused piperacillin recovered in the dialysate was 527 ± 236 mg (26.3% ± 11.8%). We suggest the replacement of 500 mg of piperacillin after each on-line HDF session.

* Corresponding author. Mailing address for Curie Ahn: Department of Internal Medicine, Seoul National University Hospital, Chongno Gu, Seoul 110-744, South Korea. Phone: 82-2-2072-2222. Fax: 82-2-741-4876. E-mail: curie{at}snu.ac.kr. Mailing address for In-Jin Jang: Department of Pharmacology and Clinical Pharmacology, Seoul National University College of Medicine and Hospital, Chongno Gu, Seoul 110-744, South Korea. Phone: 82-2-740-8290. Fax: 82-2-742-5947. E-mail: ijjang{at}snu.ac.kr

{triangledown} Published ahead of print on 18 May 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3266-3268, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01670-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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