This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Stewart, P. S.
Right arrow Articles by Steenbergen, J. N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stewart, P. S.
Right arrow Articles by Steenbergen, J. N.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 2009, p. 3505-3507, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01728-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Daptomycin Rapidly Penetrates a Staphylococcus epidermidis Biofilm{triangledown} ,{dagger}

Philip S. Stewart,1* William M. Davison,1 and Judith N. Steenbergen2

Center for Biofilm Engineering and Department of Chemical and Biological Engineering, Montana State University, Bozeman, Montana,1 Cubist Pharmaceuticals, Lexington, Massachusetts2

Received 31 December 2008/ Returned for modification 4 May 2009/ Accepted 13 May 2009

Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.

* Corresponding author. Mailing address: Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717-3980. Phone: (406) 994-4770. Fax: (406) 994-6098. E-mail: phil_s{at}biofilm.montana.edu

{triangledown} Published ahead of print on 18 May 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3505-3507, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01728-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»