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Antimicrobial Agents and Chemotherapy, August 2009, p. 3508-3510, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00285-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficacy of Combination Antifungal Therapy with Intraperitoneally Administered Micafungin and Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Aspergillosis {triangledown}

Takahiro Takazono,1,2 Koichi Izumikawa,1,2* Tomo Mihara,1,2 Kosuke Kosai,1,2 Tomomi Saijo,1,2 Yoshifumi Imamura,1,2 Taiga Miyazaki,1,2 Masafumi Seki,1,2 Hiroshi Kakeya,1,2 Yoshihiro Yamamoto,1,2 Katsunori Yanagihara,1,2,3 and Shigeru Kohno1,2

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan,1 Global Centers of Excellence Programs, Nagasaki University, Nagasaki, Japan,2 Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan3

Received 2 March 2009/ Returned for modification 28 March 2009/ Accepted 29 May 2009

Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated the effects of a combination treatment consisting of inhalation of aerosolized liposomal amphotericin B (L-AMB) with intraperitoneal administration of micafungin (MCFG) against murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with intraperitoneal MCFG significantly improved the survival rate, and the fungal burdens and histopathology findings after this treatment were superior to those of the control and both monotherapy groups.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Phone: 81 (95) 819-7273. Fax: 81 (95) 849-7285. E-mail: koizumik{at}nagasaki-u.ac.jp

{triangledown} Published ahead of print on 15 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3508-3510, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00285-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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