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Antimicrobial Agents and Chemotherapy, August 2009, p. 3511-3514, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00158-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Specific Therapeutic Schemes of Omeprazole Affect the Orientation of Helicobacter pylori{triangledown} ,{dagger}

Marina Azevedo-Vethacke, Désirée Garten, Claudia Groll, and Sören Schreiber*

Ruhr-Universität Bochum, Institut für Physiologie, Im Lottental 36, 44801 Bochum, Germany

Received 4 February 2009/ Returned for modification 5 April 2009/ Accepted 23 May 2009

Until now, it has been unclear how proton pump inhibitors (PPIs) support Helicobacter pylori therapy. We tested whether the PPI omeprazole acts on the spatial orientation of H. pylori in the gastric mucus of infected Mongolian gerbils. Following repetitive PPI administration once daily but not following single doses or administration every 8 h, the bacterial spatial distribution changed, indicating a loss of orientation. Therefore, the therapeutic scheme of PPI administration may affect efficiency of treatment.

* Corresponding author. Mailing address: Institut fuer Physiologie, Ruhr-Universitaet Bochum, Im Lottental 36, 44801 Bochum, Germany. Phone: 49-234-32 29126. Fax: 49-234-32 14191. E-mail: soeren.schreiber{at}rub.de

{triangledown} Published ahead of print on 1 June 2009.

{dagger} Supplemental material for this article may be found at http://aac.asm.org/.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3511-3514, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00158-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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