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Antimicrobial Agents and Chemotherapy, August 2009, p. 3515-3519, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00012-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Protein Kinase G Is Required for Intrinsic Antibiotic Resistance in Mycobacteria{triangledown}

Kerstin A. Wolff,{dagger} Hoa T. Nguyen,{dagger} Richard H. Cartabuke, Ajay Singh, Sam Ogwang, and Liem Nguyen*

Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106

Received 5 January 2009/ Returned for modification 5 March 2009/ Accepted 6 June 2009

Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Wood Building, 10900 Euclid Avenue, Cleveland, OH 44106-4960. Phone: (216) 368-3148. Fax: (216) 368-3055. E-mail: liem.nguyen{at}case.edu

{triangledown} Published ahead of print on 15 June 2009.

{dagger} These authors contributed equally to this research.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3515-3519, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00012-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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