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Antimicrobial Agents and Chemotherapy, August 2009, p. 3528-3533, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00178-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii{triangledown}

Marco Maria D'Andrea,1,§ Tommaso Giani,1,§ Silvia D'Arezzo,2,§ Alessandro Capone,2 Nicola Petrosillo,2 Paolo Visca,2,3 Francesco Luzzaro,4,# and Gian Maria Rossolini1,5*

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena,1 Unità Operativa di Microbiologia e Virologia, Dipartimento dei Servizi, Azienda Ospedaliera-Universitaria Senese, I-53100 Siena,5 Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, I-00149 Roma,2 Dipartimento di Biologia, Università Roma Tre, I-00146 Roma,3 Laboratorio di Microbiologia Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy4

Received 9 February 2009/ Returned for modification 21 March 2009/ Accepted 21 May 2009

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, blaOXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

* Corresponding author. Mailing address: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Santa Maria alle Scotte, I-53100 Siena, Italy. Phone: 39 0577 23 3455. Fax: 39 0577 23 3870. E-mail: rossolini{at}unisi.it

{triangledown} Published ahead of print on 1 June 2009.

§ These authors contributed equally to this work.

# Present address: A. Manzoni Hospital, Lecco, Italy.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3528-3533, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00178-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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