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Antimicrobial Agents and Chemotherapy, August 2009, p. 3534-3537, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01717-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam {triangledown}

Dao Van Hoang Nguyen,1 Quoc Phuc Nguyen,1 Ngoa Dang Nguyen,1 Thuy Thi Thanh Le,1 The Duy Nguyen,1 Duy Ngoc Dinh,1 Thanh Xuan Nguyen,2 Dai Bui,2 Marina Chavchich,3 and Michael D. Edstein3*

Department of Infectious Diseases, Military Hospital 175, Ho Chi Minh City, Vietnam,1 Department of Malaria, Military Institute of Hygiene and Epidemiology, Hanoi, Vietnam,2 Australian Army Malaria Institute, Brisbane, Queensland, Australia3

Received 25 December 2008/ Returned for modification 1 April 2009/ Accepted 3 June 2009

Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.

* Corresponding author. Mailing address: Australian Army Malaria Institute, Enoggera, Brisbane, QLD 4051, Australia. Phone: 61-7-33324801. Fax: 61-7-33324800. E-mail: mike.edstein{at}defence.gov.au

{triangledown} Published ahead of print on 15 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3534-3537, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01717-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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