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Antimicrobial Agents and Chemotherapy, August 2009, p. 3538-3540, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01106-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Synergistic Interaction between Silver Nanoparticles and Membrane-Permeabilizing Antimicrobial Peptides{triangledown}

Serge Ruden,1 Kai Hilpert,2 Marina Berditsch,1 Parvesh Wadhwani,2 and Anne S. Ulrich1,2*

KIT, IOC, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany,1 KIT, IBG-2, POB 3640, 76021 Karlsruhe, Germany2

Received 18 August 2008/ Returned for modification 13 November 2008/ Accepted 2 June 2009

Silver nanoparticles, as well as antimicrobial peptides (AMPs), can be used to fight infectious diseases. Since AMPs are known to permeabilize bacterial membranes and might therefore help silver nanoparticles to access internal target sites, we investigated their combined activities and showed synergistic effects between polymyxin B and silver nanoparticles for gram-negative bacteria.

* Corresponding author. Mailing address: KIT, IOC, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany. Phone and fax: 49-0721-6083912. E-mail: anne.ulrich{at}ibg.fzk.de

{triangledown} Published ahead of print on 15 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3538-3540, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.01106-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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