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Antimicrobial Agents and Chemotherapy, August 2009, p. 3541-3543, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00371-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

H-NS Modulates Multidrug Resistance of Salmonella enterica Serovar Typhimurium by Repressing Multidrug Efflux Genes acrEF{triangledown}

Kunihiko Nishino,1,3* Mitsuko Hayashi-Nishino,2 and Akihito Yamaguchi2,4

Laboratory of Microbiology and Infectious Diseases,1 Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Osaka 567-0047, Japan,2 PRESTO, Japan Science and Technology Corporation, Tokyo 102-0075, Japan,3 Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan4

Received 18 March 2009/ Returned for modification 29 April 2009/ Accepted 1 June 2009

Screening of Salmonella mutants for the ability to increase β-lactam resistance has led to the identification of a mutation in hns, which codes for the histone-like nucleoid structuring protein (H-NS). In this study, we report that H-NS modulates multidrug resistance through repression of the genes that encode the AcrEF multidrug efflux pump in Salmonella enterica serovar Typhimurium.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. Phone: 81-6-6879-8546. Fax: 81-6-6879-8549. E-mail: nishino{at}sanken.osaka-u.ac.jp

{triangledown} Published ahead of print on 8 June 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3541-3543, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00371-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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