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Antimicrobial Agents and Chemotherapy, August 2009, p. 3549-3551, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00184-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes {triangledown}

Eric Dannaoui,1,2* Patrick Schwarz,1 and Olivier Lortholary1,3

Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3012, 75724 Paris, Cedex 15, France,1 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Paris, France,2 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Paris, France3

Received 10 February 2009/ Returned for modification 7 March 2009/ Accepted 9 May 2009

The in vitro interaction of antifungals with immunosuppressive drugs was evaluated against zygomycetes. The combination of amphotericin B with cyclosporine, rapamycin, or tacrolimus was synergistic for 90%, 70%, and 30% of the isolates, respectively. For posaconazole, itraconazole, and ravuconazole, synergy was more frequently observed with cyclosporine than with rapamycin or tacrolimus and antagonistic interactions were rarely noted. In summary, calcineurin inhibitors and rapamycin can be synergistic in vitro with amphotericin B and azoles against zygomycetes.

* Corresponding author. Mailing address: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris, Cedex 15, France. Phone: 33 1 40 61 32 50. Fax: 33 1 45 68 84 20. E-mail: dannaoui{at}pasteur.fr

{triangledown} Published ahead of print on 18 May 2009.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3549-3551, Vol. 53, No. 8
0066-4804/09/$08.00+0     doi:10.1128/AAC.00184-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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